Rocky Lhotka had this over on his site:
Never directly interact with a business object while it is data bound - only interact with the bindingsource
http://forums.lhotka.net/forums/thread/22990.aspx
I have to say, I am guilty of doing this, and I didn't even know it was considered a bad practice, but I do recall running into problems with the behavior in getting the UI to refresh as I would want it to.
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