I just got to the bottom of this problem…
I was running Greenshot from startup (Greenshot is a nice OSS screen capture tool), and I was having this issue where from time to time the “print” wouldn’t work.
When running Greenshot, pressing the Print key allows you to select a region of the screen for a cropped screen shot.
After some tinkering, the issue is that when Greenshot is running w/o admin rights, it won’t be able to respond when my focus is on an application that is running WITH admin rights.
As long as the app I have focus on is using regular level permissions, or greenshot is running with elevated premissions, all is well.
I’m simply running it with elevated permissions now and have no issues.